The Alpha Quadrant is one of four regions of the Milky Way Galaxy. Prominent powers in this region include the United Federation of Planets, the Hydran Sovereignty, the Kzinti Patriarchy, the Breen Confederacy, the T'Kith'Kin Hive, the Sheliak Corporate, the Ferengi Alliance, the Tzenkethi Coalition, the Ubarrek Primacy, the Talarian Republic, and the Tholian Assembly. Prominent stellar phenomena include the Black Cluster, the Badlands, the Hugora Nebula, and the Bajoran Wormhole.

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